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Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis. This study aims to obtain more insight into the safety profile of montelukast and to provide prescribing physicians with an overview of relevant adverse drug reactions in both children and adults. We retrospectively studied all adverse drug reactions on montelukast in children and adults reported to the Netherlands Pharmacovigilance Center Lareb and the WHO Global database, VigiBase ® until 2016. Depression was reported most frequently in the whole population to the global database VigiBase ® (reporting odds ratio (ROR) ; 95% CI: –). In the VigiBase ® , aggression was reported the most in children (ROR, ; 95% CI: –). Headaches were reported the most frequently to the Dutch database (ROR, ; 95% CI: –). Furthermore, nightmares are often reported for both children and adults to the Dutch and the global database. Eight patients with allergic granulomatous angiitis were reported to the Dutch database and 563 patients in the VigiBase ® . These data demonstrate that montelukast is associated with neuropsychiatric adverse drug reactions such as depression and aggression. Especially in children nightmares are reported frequently. Allergic granulomatous angiitis is also reported, a causal relationship has not been established.

Arthritis Research & Therapy is a leading journal in the field of rheumatology and is notable for the breadth and quality of articles on the broad range ...

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Various methods can be used to evaluate abstract quality, . rating by readers, checklists (not necessary in structured abstracts), and readability measures (such as Flesch Reading Ease ). [16] [20]

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abstract on a research paper

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abstract on a research paper

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abstract on a research paper

Abstract on a research paper

Arthritis Research & Therapy is a leading journal in the field of rheumatology and is notable for the breadth and quality of articles on the broad range ...

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abstract on a research paper
Abstract on a research paper

To help us improve your journal reading experience, this website uses cookies. Learn more about cookies and how to change your settings in our Cookie Policy . You can also read our Privacy Policy .

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Abstract on a research paper

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abstract on a research paper

Abstract on a research paper

Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis. This study aims to obtain more insight into the safety profile of montelukast and to provide prescribing physicians with an overview of relevant adverse drug reactions in both children and adults. We retrospectively studied all adverse drug reactions on montelukast in children and adults reported to the Netherlands Pharmacovigilance Center Lareb and the WHO Global database, VigiBase ® until 2016. Depression was reported most frequently in the whole population to the global database VigiBase ® (reporting odds ratio (ROR) ; 95% CI: –). In the VigiBase ® , aggression was reported the most in children (ROR, ; 95% CI: –). Headaches were reported the most frequently to the Dutch database (ROR, ; 95% CI: –). Furthermore, nightmares are often reported for both children and adults to the Dutch and the global database. Eight patients with allergic granulomatous angiitis were reported to the Dutch database and 563 patients in the VigiBase ® . These data demonstrate that montelukast is associated with neuropsychiatric adverse drug reactions such as depression and aggression. Especially in children nightmares are reported frequently. Allergic granulomatous angiitis is also reported, a causal relationship has not been established.

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abstract on a research paper

Abstract on a research paper

Arthritis Research & Therapy is a leading journal in the field of rheumatology and is notable for the breadth and quality of articles on the broad range ...

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abstract on a research paper

Abstract on a research paper

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Abstract on a research paper

Various methods can be used to evaluate abstract quality, . rating by readers, checklists (not necessary in structured abstracts), and readability measures (such as Flesch Reading Ease ). [16] [20]

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Abstract on a research paper

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